Brandon Chase
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Articles by Brandon Chase
Simple Blood Test May Predict Alzheimer’s Years Before Brain Scans Show Signs
A long-term study suggests that a specific blood biomarker may reveal the earliest biological shifts linked to Alzheimer’s disease, even before conventional brain imaging detects them. Credit: Stock Mass General Brigham researchers used long-term data and a blood test for the biomarker pTau217 to identify the earliest signs of Alzheimer’s disease in cognitively healthy adults.
Review: Ezio’s Brings Italian Cooking and Serious Steaks to North Beach
MIAMI | FLORIDA EZIO’S | $$$$$ | MAP | INSTAGRAM By Brandon Chase | April 14, 2026 AUTHOR BIO: Brandon Chase is a Miami personal injury attorney who has a deep knowledge of wine and food, built by marrying into an Italian family. Email him here. Ezio’s had my attention before dinner started. The new Italian steakhouse in North Beach is from the co-founders and chefs behind Roberta’s Pizza, Foul Witch, and Blanca, and that kind of background tends to come with expectations.
Even With a Few Early Wobbles, Mottai Brings Ambition to Coral Gables
MIAMI | FLORIDA $$$$$ | MAP | WEBSITE | INSTAGRAM By Brandon Chase | April 4, 2026 AUTHOR BIO: Brandon Chase is a Miami personal injury attorney who has a deep knowledge of wine and food, built by marrying into an Italian family. Email him here. At Mottai, the Plaza Coral Gables finally gets the kind of high-end Japanese concept it’s been missing—one that feels intentional, ambitious, and, at times, genuinely excellent. The room alone makes a statement.
Mika Review: Michael White Brings Riviera Glamour—and Serious Pasta—to Miami
MIAMI | FLORIDA $$$$$ | MAP | WEBSITE | INSTAGRAM By Brandon Chase | Dec. 24, 2025 AUTHOR BIO: Brandon Chase is a Miami personal injury attorney who has a deep knowledge of wine and food, built by marrying into an Italian family. Email him here. From the moment you step inside Mika, it’s clear that this is not just another Miami opening—it’s a transportive experience.
Dinner in a Cadillac? COTE’s Latest Miami Stunt Puts Korean BBQ in the Back Seat
Written by Brandon Chase | June 16, 2025 AUTHOR BIO: Brandon Chase is a Miami personal injury attorney who has a deep knowledge of wine and food, built by marrying into an Italian family. Email him here. Pull up in a brand-new Cadillac Escalade IQ, slide into massaging leather seats, and suddenly you’re not just dining—you’re experiencing Michelin-level Korean BBQ inside a rolling monument to luxury.
Potential Alzheimer’s disease therapeutic target identified in brain immune cells
Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now.
Low-dose carbon monoxide may explain the paradoxical reduced risk of Parkinson's disease among smokers
Paradoxically, previous research has shown that despite its inherent health risks, cigarette smoking is linked with a reduced risk of Parkinson's disease (PD). Until now, however, it was not clear how. New research in lab models indicates that low doses of carbon monoxide—comparable to that experienced by smokers —protected against neurodegeneration and prevented the accumulation of a key PD-associated protein in the brain.
Study discovers a 'brain thesaurus' that lets neurons derive meaning from spoken words
Using a novel technology for obtaining recordings from single neurons, a team of investigators at Massachusetts General Hospital, a founding member of the Mass General Brigham health care system, discovered a microscopic "thesaurus" that reflects how word meanings are represented by neurons in the human brain.
Study reveals genetic clusters that may explain differences in type 2 diabetes risk
The development and progression of type 2 diabetes are affected by numerous biological processes, such as the body’s response to insulin, the health of insulin-producing pancreatic beta cells, and the functioning of metabolic pathways.
Study reveals genetic clusters and biological pathways that may explain differences in type 2 diabetes risk
The development and progression of type 2 diabetes are affected by numerous biological processes, such as the body's response to insulin, the health of insulin-producing pancreatic beta cells, and the functioning of metabolic pathways.
Substudy of trial reveals how statin therapy prevents cardiovascular disease in people with HIV
A recent clinical trial reveals how a daily statin pill may prevent heart attacks and strokes in people with HIV. In this substudy of the phase 3 Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE), a team led by investigators at Massachusetts General Hospital (MGH) discovered that pitavastatin reduces plaque buildup in the heart's coronary arteries and lowers inflammation in the blood. The findings are published in JAMA Cardiology.
A newly characterized form of tau may be involved in initiating Alzheimer's disease
The tau protein accumulates in abnormal shapes in the brains of individuals with Alzheimer's disease (AD), but the early steps of tau misfolding and aggregation are unknown. A team led by investigators at Massachusetts General Hospital (MGH) and Boston Children's Hospital, recently used advanced proteomics methods to identify a new soluble form of tau that may be involved in these initiating steps. In their work, which is published in the journal Brain, senior authors Bradley T.
Researchers identify a potential target for reversing poor metabolic traits
During oxidative stress, excess production of reactive oxygen species causes cell and tissue damage. Reductive stress is the counterpart of oxidative stress and occurs when cells build up too much of a molecule called NADH (nicotinamide adenine dinucleotide + hydrogen), which plays a role in energy production.
Tobacco smoke exposure linked to increased risk of tuberculosis
Researchers at Massachusetts General Hospital (MGH) have identified a potential mechanism by which tobacco smoking drives a type of white blood cell known as monocytes to the lung where they can increase the risk of active tuberculosis (TB).
Researchers identify a new small molecule inhibitor for use against Alzheimer's disease
In people with Alzheimer's disease (AD), the epigenetic regulator HDAC6 (histone deacetylase 6), which controls many biological processes, is significantly overexpressed in the brain. Evidence suggests that HDAC6 is closely related to amyloid and tau pathology, the two primary hallmarks of AD.
Researchers develop technology to tabulate and characterize every cell in the human brain
The brain is made up of numerous types of cells that are organized into different structures and regions. Although several important steps have been made towards building models of the human brain, the advances have not produced undistorted 3D images of cellular architecture that are needed to build accurate and detailed models.
New human cell-based 3D model reveals insights into how immune cells contribute to Alzheimer's disease
Cognitive decline associated with Alzheimer's disease (AD) develops when neurons begin to die, which can be caused by inappropriate immune responses and excessive inflammation in the brain triggered by amyloid beta deposits and tau tangles, two hallmarks of the disease. Also, immune cells outside of the brain, particularly T cells, can enter the brain and worsen AD pathology, but studying this process has been difficult.
Symptoms previously considered 'defective' in patients with language disorder may actually be adaptive
Individuals with a language disorder called non-fluent aphasia—which may result from a stroke, head injury, or neurodegeneration find it difficult to speak in complex sentences, and they have various word-level abnormalities, including using fewer verbs and fewer function words such as pronouns and prepositions.
Massachusetts General Hospital Launches First-of-its-Kind Center for Clinical Transplant Tolerance
BOSTON – Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham health system, officially opened the Legorreta Center for Clinical Transplant Tolerance, the first-of-its kind center in the world dedicated to preventing organ rejection after transplant surgery without the use of lifelong immunosuppressive medications.
Too busy for daily exercise? Be a ‘weekend warrior.’
People for whom it’s difficult to find time to exercise during a busy work week may concentrate their moderate-to-vigorous physical activity to one to two days of the week or weekend. In a recent analysis published in JAMA that was conducted by investigators at Massachusetts General Hospital, this “weekend warrior” pattern was associated with similarly lower risks of heart disease and stroke compared with more evenly distributed exercise.
Study sheds light on how breast cancer cells evade immune surveillance and survive in lymph nodes
In breast cancer, nearby lymph nodes, which are part of the immune system, are usually the first site of cancer spread, and from here cancer cells can travel to other parts of the body, such as the brain, lung, liver, and bones. New research led by investigators at Massachusetts General Hospital (MGH) reveals how cancer cells suppress anti-cancer immune responses in the lymph nodes to survive and spread, or metastasize.
Limiting opioids during surgery may lead to more postoperative pain and opioid use for patients Original
Because of the opioid crisis, physicians are less likely to administer opioids to help manage patients' pain, even in the operating room. A recent analysis in JAMA Surgery conducted by investigators at Massachusetts General Hospital (MGH) indicates that overly restricting use of opioids during surgery may be doing more harm than good. For the study, researchers analyzed information on 61,249 adults who had surgery at MGH from 2016–2020.
Is drinking in moderation good for your heart?
A new study led by investigators from Massachusetts General Hospital offers an explanation for why light to moderate alcohol consumption may be associated with lower risk of heart disease. For the first time, researchers found that alcohol, in light to moderate quantities, was associated with long-term reductions in stress signaling in the brain. This impact appeared to significantly account for the reductions in heart disease risk seen in light to moderate drinkers participating in the study.
Alzheimer's disease plasma biomarker contributes to postoperative delirium-like behavior in rodents
Tauopathy is one of the hallmarks of Alzheimer's disease (AD) pathogenesis, and the phosphorylation of Tau at threonine 217 (Tau-PT217) and 181 (Tau-PT181) represents new plasma biomarkers capable of detecting early-stages of AD. Additionally, preoperative plasma levels of Tau-PT217 and Tau-PT181 serve as biomarkers of postoperative delirium in older patients. Moreover, plasma levels of Tau-PT217 and Tau-PT181 increase following anesthesia and surgery in patients.
Gut bacteria may contribute to delirium in elderly patients after surgery
Postoperative delirium—a sudden, fluctuating and typically reversible disturbance of mental status in patients that occurs after anesthetized surgery—is a common postoperative complication. The causes, progression and biological signatures are largely unknown, however. Now researchers at Massachusetts General Hospital, a founding member of Mass General Brigham, and colleagues have conducted a first-of-its-kind study that shows an association between gut microbiota and postoperative delirium.
Airways of individuals with asthma found to have higher expression of genes that amplify inflammation
The strongest risk factor for developing asthma is the presence of allergies, but it's unclear why only some individuals with allergies go on to develop asthma. A team led by investigators at Massachusetts General Hospital (MGH) has identified the key differences in the airway response to allergens between people with allergic asthma and people with allergies but no asthma.
Genetic therapy corrects progressive muscle disorder in mice
People with myotonic dystrophy experience progressive muscle weakness and repeated episodes of painless muscle stiffness called myotonia. Investigators at Massachusetts General Hospital (MGH) recently used a targeted drug to restore muscle strength and correct myotonia in mice with myotonic dystrophy. The research, which is published in Nature Communications, could lead to new treatments for affected patients.
Protein deficiency in neurons of patients with neurodegenerative diseases could be targeted by new gene therapy approach Original
TDP-43 is an RNA-binding protein that normally resides in the nucleus of neurons but is abnormally located in the cytoplasm of neurons in most patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, and up to half of patients with Alzheimer's disease.
Using AI to target Alzheimer’s
Although investigators have made strides in detecting signs of Alzheimer’s disease using high-quality brain imaging tests collected as part of research studies, a team at Massachusetts General Hospital recently developed an accurate method that relies on routinely collected clinical brain images. The advance could lead to more accurate diagnoses. For the study, published in PLOS ONE, Matthew Leming, a research fellow at Mass.
Artifical intelligence approach may help detect Alzheimer's disease from routine brain imaging tests
Although investigators have made strides in detecting signs of Alzheimer's disease using high-quality brain imaging tests collected as part of research studies, a team at Massachusetts General Hospital (MGH) recently developed an accurate method for detection that relies on routinely collected clinical brain images. The advance could lead to more accurate diagnoses.
Ohio train derailment: EPA administrator visits East Palestine, asks residents to 'trust the government'
(EAST PALESTINE, Ohio) -- The mayor of an Ohio village where a train carrying toxic chemicals derailed earlier this month told ABC News that he "wasn't built for this" and needs "help." East Palestine Mayor Trent Conaway briefly spoke to reporters on Wednesday evening, before a town hall meeting with residents in the local high school's gymnasium.
Ohio train derailment: East Palestine mayor says he needs 'help' ahead of EPA administrator's visit Original
"I wasn't built for this," East Palestine Mayor Trent Conaway told ABC News. EAST PALESTINE, Ohio -- The mayor of an Ohio village where a train carrying toxic chemicals derailed earlier this month told ABC News that he "wasn't built for this" and needs "help." East Palestine Mayor Trent Conaway briefly spoke to reporters on Wednesday evening, before a town hall meeting with residents in the local high school's gymnasium.
Resort Report: Point Grace Resort, Turks & Caicos
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New CRISPR-Cas approach permits more precise DNA cleavage
A team led by investigators at Massachusetts General Hospital (MGH) has overcome a major constraint for cutting and editing DNA by CRISPR-Cas enzymes and other technologies. The recent innovation, which is published in Nature Biotechnology, will simplify and expedite molecular cloning approaches and expand their utility.
The 180-km-long Meers-Willow Fault System in the Southern Oklahoma Aulacogen: A potential U.S. mid-continent seismic hazard
We integrate new high-resolution aeromagnetic data with seismic reflection data, well logs, satellite remote sensing, and field observations to provide a regional view of buried and exposed structures in the Southern Oklahoma Aulacogen and to assess their potential for future seismicity.
A Brief History of American Money
Advertiser Disclosure: This site is part of an affiliate sales network and receives compensation for sending traffic to partner sites, such as CardRatings.com. This compensation may impact how and where links appear on this site. This site does not include all financial companies or all available financial offers. Opinions, reviews, analyses & recommendations are the author’s alone, and have not been reviewed, endorsed or approved by any of these entities.
Grow 2 Give
by Brandon Chase Support for cancer patients is a cause that's personal to me, especially when that support is financial. When my father battled cancer for 2.5 years before he passed away in 2013, our family, like so many others facing a cancer diagnosis, faced financial struggles. In 2013, we received support from the Joe Andruzzi Foundation, and eight years later, I'm paying it forward, working for them and providing assistance to patients and families throughout New England.
Boston Sportswriter Gets His Turn in the Spotlight Running Marathon to Support Cancer Patients
Steve Hewitt is used to telling athletes’ stories. He’s been a sports reporter for The Boston Herald since 2014, assisted with coverage of the Red Sox’ World Series victory in 2018, and was named the newspaper’s Red Sox beat writer in 2019. Now, it’s Steve’s turn to be an athlete in the spotlight as part of Team JAF, the Joe Andruzzi Foundation group of runners who participate in charity races on behalf of the Foundation.
Brandon Chase and Will Brewington III on The Color Brown
Brandon Chase and Will Brewington III on The Color Brown Filmmakers Brandon Chase and Will Brewington III join us to discuss their upcoming short film, "The Color Brown," which was filmed in Erie, PA. This film tells the story of two siblings - both previously unaware of the other - who meet following the passing of a relative.
Kaleigh Fratkin isn’t just one of the NWHL’s top defenders. She’s also the coach of the Weymouth girls’ hockey team
© Michelle Jay for The Boston Globe Boston Pride defender Kaleigh Fratkin, the first-year coach of Weymouth girls' hockey team, skates out to the ice during pregame introductions before a Jan. 24 NWHL game in Lake Placid, N.Y. Returning after a 14-day COVID-19 pause, the Weymouth girls’ hockey team was readying for Saturday’s return for their game against the Newton Crush co-op. Game prep this winter often requires players to make final preparations outside.
DAREDEVIL | Lane's End
Leading third-crop sire Daredevil is the sire of sensations Swiss Skydiver and Shedaresthedevil, Daredevil is the #1 North American Third-Crop Sire by Graded Stakes winners in 2021. Daredevil is the only first-crop sire to ever sire an individual winner of the Kentucky Oaks and the Preakness Stakes in the same year. Swiss Skydiver is only the sixth filly to win the second leg of the Triple Crown in its 145 year history and only the second since Nellie Morse in 1924.
Running The Ultra Trail Cape Town's Epic 65km Route
Seeing as there were no trail running races taking place during my recent visit to Cape Town, South Africa, I decided to construct my own adventure from the route used by the Ultra Trail Cape Town race. The Ultra Trail Cape Town race takes place in November and winds through and around Table Mountain National Park in the Western Cape, so it offers plenty of opportunity for challenging climbs, diverse landscapes and beautiful views.
The coronavirus dilemma: Are we using ventilators too much?
Juanmonino/iStockBy DR. NANCY A. ANORUO, ABC News (NEW YORK) — As hospitals seek innovative solutions to treat the surge of COVID-19 patients with resources running thin, expanding ventilator supply has been central to the conversation. Research has shown that only a third of patients placed on a ventilator survive the experience. Now, some experts are wondering if ventilators could be contributing to the poor survival rate and whether ventilators are being overused.
Woman, newborn reunited 25 days after emergency C-section due to COVID-19 - Health News - ABC News Radio
ABC NewsBy BRANDON CHASE and ENJOLI FRANCIS, ABC News (NEW YORK) -- It was a moment that Iris Nolasco had been anticipating for nearly a month, but at the same time could not believe was happening: She was finally meeting her baby girl for the first time, face-to-face, 25 days after the infant has been born.
KTBB.com - News Weather Talk
Woman, newborn reunited 25 days after emergency C-section due to COVID-19 Posted/updated on: April 22, 2020 at 6:45 am ABC NewsBy BRANDON CHASE and ENJOLI FRANCIS, ABC News (NEW YORK) -- It was a moment that Iris Nolasco had been anticipating for nearly a month, but at the same time could not believe was happening: She was finally meeting her baby girl for the first time, face-to-face, 25 days after the infant has been born.
Woman, newborn reunited 25 days after emergency C-section due to COVID-19
By BRANDON CHASE and ENJOLI FRANCIS, ABC News (NEW YORK) -- It was a moment that Iris Nolasco had been anticipating for nearly a month, but at the same time could not believe was happening: She was finally meeting her baby girl for the first time, face-to-face, 25 days after the infant has been born.
Woman, newborn reunited 25 days after emergency C-section due to COVID-19
Iris Nolasco finally met Isabella Michelle after more than three weeks. April 21, 2020, 10:54 PM 8 min read It was a moment that Iris Nolasco had been anticipating for nearly a month, but at the same time could not believe was happening: She was finally meeting her baby girl for the first time, face-to-face, 25 days after the infant has been born.
At Maimonides Medical Center, mourning the loss of a teammate and noting small wins
The staff discussed supply shortages and retrainings. April 15, 2020, 1:11 PM 5 min read The morning call was a mix of emotions for those attending at Maimonides Medical Center. On Tuesday, Michael Antoniades, the executive vice president and chief operating officer, sat at the head of the long table, donning dark-framed glasses, a white shirt and a mask -- pulled down so he could be heard -- as he addressed staff present and on the phone in Brooklyn, New York.
Cambodia's Epic Ultramarathon Event
All opinions are our own and never influenced by brands. We may earn money if you buy from a link. The time was 3:00am, and I was shaking off the cobwebs of a short nights’ sleep while riding in a minibus down a dusty, bumpy road in Siem Reap, Cambodia. I was heading to the start line of the Angkor Ultra-Trail (UTA), where six races of varying lengths were taking place that day.
LETTER TO THE EDITOR: More discretion needed for student discipline
Letters Written By: Brandon Chase, Park Rapids | Oct 2nd 2019 - 3pm. My grandsons were recently awarded a three-day vacation for allegedly vaping on the bus. Coupled by the weekend, it amounts to five days of no school. They were ecstatic. I was livid. Not only because of their alleged activity, but because of the cookie-cutter punishment they received. I have reached out to school administration about this.
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