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Articles

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia

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By Lika Apriani, Ayesha Verrall, Todia P Setiabudiawan, Fitria Utami
| biorxiv.org
Abstract Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by an IFN-γ-independent adaptive immune response, or an effective innate host response clearing Mycobacterium tuberculosis (Mtb) without adaptive immunity.
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