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Flavia Barragan on Muck Rack

Flavia Barragan

As seen in: Color Research & Application
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Articles

A Solid Phase Approach to Accessing Bisthioether Stapled Peptides Resulting in a Potent Inhibitor of PRC2 Catalytic Activity

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By Guillermo Gerona-Navarro, Gan Zhang, Flavia Barragan, Khadija Wilson
| pericles.pericles-prod.literatumonline.com
Stapled peptides have emerged as a new class of therapeutics to effectively target intractable protein‐protein interactions. Thus, efficient and versatile methods granting easy access to this class of compounds and expanding the scope(s) of the currently available ones are of great interest. Here, we describe a solid phase approach for the synthesis of bisthioether stapled peptides with multiple architectures, including single‐, double‐turn and double‐stapled macrocycles.
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A Solid Phase Approach to Accessing Bisthioether Stapled Peptides Resulting in a Potent Inhibitor of PRC2 Catalytic Activity

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By Guillermo Gerona-Navarro, Gan Zhang, Flavia Barragan, Khadija Wilson
| Arthritis & Rheumatology Verified
Stapled peptides have emerged as a new class of therapeutics to effectively target intractable protein‐protein interactions. Thus, efficient and versatile methods granting easy access to this class of compounds and expanding the scope(s) of the currently available ones are of great interest. Here, we describe a solid phase approach for the synthesis of bisthioether stapled peptides with multiple architectures, including single‐, double‐turn and double‐stapled macrocycles.
Open in Who Shared Issue with article?
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