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Flaviene Felix

As seen in: MDPI
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Articles

FoxO3 and oxidative stress: a multifaceted role in cellular adaptation - Journal of Molecular Medicine

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By Victoria Simões, Flaviene Felix, da Silva, Danilo Grünig Humberto
| link.springer.com
Abstract Oxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively studied transcription factor that plays a pleiotropic role in a wide range of physiological and pathological processes by regulating multiple gene regulatory networks involved in the modulation of numerous aspects of cellular metabolism, including fuel metabolism, cell death, and stress resistance.
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Genes | Free Full-Text | Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells

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By Victoria Bernardo, Flaviene Felix Torres, Victoria Simões, Flaviene Felix
| MDPI
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Influence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells

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By Victoria Bernardo, Flaviene Felix Torres, Flaviene Felix, Victoria Simões
| MDPI
Abstract : Melatonin (MEL) presents well-documented pleiotropic actions against oxidative stress (OS), acting indirectly through activation of transcription factors, e.g., FoxO3 and Nrf2. Thus, this study aimed to investigate the possible modulating effects of MEL on the redox signaling pathways PI3K/AKT/FoxO3 and Keap1/Nrf2/ARE in K562 erythroleukemic cells subjected to OS induction.
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