Fleurie Kelley on Muck Rack

Fleurie Kelley

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Articles

Controlled and orthogonal partitioning of large particles into biomolecular condensates - Nature Communications

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By Fleurie Kelley, Bridget Linders, Mayur Barai, Yuwei Gu
| Nature Verified
Abstract Partitioning of client molecules into biomolecular condensates is critical for regulating the composition and function of condensates. Previous studies suggest that client size limits partitioning. Here, we ask whether large clients, such as macromolecular complexes and nanoparticles, can partition into condensates based on particle-condensate interactions.
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Controlled and orthogonal partitioning of large particles into biomolecular condensates

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By Fleurie Kelley, Anas Ani, Emily Pinlac, Bridget Linders
| biorxiv.org
Abstract Biomolecular condensates arising from liquid-liquid phase separation contribute to diverse cellular processes, such as gene expression. Partitioning of client molecules into condensates is critical to regulating the composition and function of condensates. Previous studies suggest that client size limits partitioning, with dextrans >5 nm excluded from condensates.
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