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EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder
Data Availability Statement The WGS data can be found under study accession number PRJEB16012 and sample accession numbers SAMEA114382052 (case 1), SAMEA114382053 (case 2), and SAMEA114382054 (case 3) at the European Nucleotide Archive. All other accession numbers are given in Supporting Information Table S1.
Perinatal dysfunction of innate immunity in cystic fibrosis
Editor’s summary The use of CFTR modulators for the treatment of cystic fibrosis has led to substantial improvement in lung function, but problems with inflammation and infection persist. In Jaudas et al., the authors characterized the innate immune systems in CFTR-deficient pigs and found higher pulmonary infiltration of monocytes compared with that in wild-type pigs, even at birth.
Proteomic profiling of equine airway mucus reveals compositional changes in asthmatic phenotypes - Scientific Reports
Abstract Mucus hypersecretion and accumulation are hallmark features of equine asthma (EA), a meaningful respiratory disorder in horses occurring in mild to moderate (MEA) and severe (SEA) forms. Changes of the proteomic composition of airway mucus in EA are poorly understood. Using label-free quantitative liquid chromatography-mass spectrometry, we analyzed airway mucus from SEA (n = 10), MEA (n = 6), and healthy (n = 8) horses.
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