Fokion Spanos on Muck Rack

Fokion Spanos

As seen in: Nature
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Articles

Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism - Nature Communications

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By María Illescas, Thomas Gasser, Cristina Ugalde, Fokion Spanos, Alessandra Maria Calogero, Marvin Oldrati, Graziella Cappelletti
| Nature
Abstract Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher’s disease, are the most frequent genetic risk factor for Parkinson’s disease (PD). Here, we employ global proteomic and single-cell genomic approaches in stable cell lines as well as induced pluripotent stem cell (iPSC)-derived neurons and midbrain organoids to dissect the mechanisms underlying GCase-related neurodegeneration.
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