Fong Wilson Lam

Keywords Animals, Disseminated Intravascular Coagulation, Fibrin, Inflammation, Mice, Thrombosis, von Willebrand Factor Abstract Systemic inflammation can lead to coagulopathy and disseminated intravascular coagulation (DIC). In prior studies, the recombinant A2 domain of human von Willebrand factor (VWF; A2 protein) attenuated DIC and decreased mortality in lipopolysaccharide (LPS)-treated mice. Here, we performed studies to dissect the mechanism by which the A2 protein moderates DIC.

Keywords Animals, Cell Adhesion, Disease Models, Animal, Endothelium, Endotoxemia, Female, Healthy Volunteers, Human Umbilical Vein Endothelial Cells, Humans, Interferometry, Leukocytes, Male, Membrane Glycoproteins, Molecular Docking Simulation, P-Selectin, Protein Binding, Protein Domains, Recombinant Proteins, Vimentin Abstract Acute inflammation begins with leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin on inflamed endothelium and platelets.