Fonma Essien

Human HPV-associated HNSCC SCC090 (RRID: CVCL_1899), SCC152 (RRID: CVCL_C058), SCC 154 (RRID: CVCL_2230), and UDSCC2 (RRID: CVCL_E325) and HPV-independent cell lines UMSCC22A (RRID: CVCL_7731), HN30 (RRID: CVCL_5525), HN31 (RRID: CVCL_5526) and UMSCC47 (RRID:CVCL 7759) were maintained in high glucose DMEM, MEM or RPMI as previously described [20, 21], supplemented with 10% fetal bovine serum, 1% glutamine, 1% vitamins, 1% non-essential amino acids, 1% penicillin/streptomycin, 1% sodium...

Abstract Purpose: Exposomes are critical drivers of carcinogenesis. However, how they modulate tumor behavior remains unclear. Extensive clinical data link cigarette smoke as a key exposome that promotes aggressive tumors, higher rates of metastasis, reduced response to chemoradiotherapy, and suppressed anti-tumor immunity.