Fpo Irccs

In the DP3 study, all men are Caucasian and recruited in the North-West of Italy (Biella and Turin). In particular, 421 men (age range: 50–69) undergoing opportunistic PSA screening at Fondazione Edo ed Elvo Tempia (FEET) were prospectively recruited between September 2021 and October 2023. Blood sampling was carried out at recruitment and every six months, for at least three times. All the recruited subjects were checked by a urologist and underwent DRE.

Epigenetic modifications are associated with distinct stages of autoreactive CD8+ T cell differentiation. DNA methylation and chromatin changes guide the acquisition of a memory-like phenotype and sustain prolonged autoimmune effector responses. Fig. 1: Epigenetic dynamics during T cell differentiation. References 1. Hashimoto, M. et al. Annu. Rev. Med. 69, 301–318 (2018). 2. Yeo, L. et al. J. Clin. Invest. 128, 3460–3474 (2018). 3. Skowera, A. et al. Diabetes 64, 916–925 (2015). 4. Abdelsamed, H. A. et al. Nat. Immunol.