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1 THE VULNERABLE WONDER CROP Cassava is an important and versatile staple tropical root crop that feeds around 800 million people worldwide (Figure 1a). In Africa an estimated 500 million people consume cassava daily and for half of these people cassava is their main source of calories. Cassava plants are drought tolerant, need little input and can grow in marginal land where other crops do not thrive.
(Molecular Cell 79, 710–727; September 3, 2020) In this review, the authors accidentally depicted the wrong structure for sofosbuvir in Figure 2 and Table 2. The correct structure now appears with the article online in both Figure 2 and Table 2. The authors also depict the prodrug structure of NHC in the updated article. The corrected and the original versions of Figure 2 appear below. The authors apologize for the error.
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nucleoside analogs (NAs), exert their effect by incorporation into viral genomes and subsequent disruption of viral replication and fidelity.
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