Francesca Benedetta Pizzini

Abstract Cortical lesions have evolved from a largely overlooked pathological feature to a central component of multiple sclerosis pathophysiology, yet their biology, clinical relevance and response to treatment remain incompletely understood. In this Review, we trace how pathological studies established the frequency and heterogeneity of cortical demyelination, with particular attention to subpial lesions and inflammation at the brain–cerebrospinal fluid interface.

39. Sandström H. Variability in target delineation in stereotactic radiosurgery with Leksell Gamma Knife Perfexion and a perspective on radiobiological outcome: a multiobserver study. Master of Science Thesis. Department of medical radiation physics. Stockholm: Stockholm University;