Francesco Bartoli
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Kdm2a histone demethylase ablation restores anti-tumor immunogenicity in liver cancer
Abstract Liver cancer remains a major global challenge, with limited benefit from immune checkpoint inhibitors due to strong immune evasion. Emerging evidence indicates that chromatin modifiers shape tumor immunogenicity, but their roles in liver cancer immunity are not fully understood. We investigated the role of the histone demethylase KDM2A in liver cancer using genetic silencing in vitro and in vivo.
Clinical and Sociodemographic Correlates of Poor Medication Adherence in People With Bipolar Disorder: A Systematic Review and Meta-Analysis
1 Introduction Bipolar disorder (BD) is a severe and chronic condition, affecting around 2% of the general population [1, 2]. The clinical course is characterized by mood recurrences, in which manic or hypomanic episodes may alternate to depressive episodes [3]. Notwithstanding the availability of several effective therapeutic options for BD, research has shown that different individual and environmental factors are associated with clinical relapses in BD [4].
The Promise of Long-acting Injectable Antipsychotics for the Treatment of Bipolar I Disorder: The Role of Manic Predominance
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