Franciane Chevot on Muck Rack

Franciane Chevot

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Queuine Analogues Incorporating the 7‐Aminomethyl‐7‐deazaguanine Core: Structure-Activity Relationships in the Treatment of Experimental Autoimmune Encephalomyelitis - Cotter - ChemMedChem - Wiley Online Library

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By Michelle Cotter, Sreeja Varghese, Franciane Chevot, Claire Fergus
| Wiley Online Library Verified
Graphical Abstract The activity of preQ1 7-deazaguanine analogues in a murine model of multiple sclerosis has been investigated. This revealed an unusually narrow SAR characterised by the requirement for a three-carbon chain linking the preQ1-core to a (preferably unsubstituted) aromatic ring. Deviations from this core structure led to dramatic losses in activity in vitro and in vivo.
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