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Francis E. Reyes on Muck Rack

Francis E. Reyes

As seen in: Texas Medical Center
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Articles

Cannabis Use and Sinonasal Symptoms in US Adults

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By Francis Reyes Orozco, Matthew Lin, Kevin Hur, Francis E. Reyes
| Texas Medical Center
IMPORTANCE: Cannabis is the most commonly used illicit substance in the US and worldwide. Understanding the association between cannabis use and sinonasal symptoms may help clinicians and patients better understand the symptomatology associated with cannabis use. OBJECTIVE: To assess the association between frequency of cannabis use and presence of sinonasal symptoms in a nationally representative sample of US adults.
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The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7 - Journal of the American Chemical Society (ACS Publications)

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By Stephen McCarthy, Rachael Dickman, Francis E. Reyes, Silvia Sanchez-Martinez
| American Chemical Society
Spider venom toxins, such as Protoxin-II (ProTx-II), have recently received much attention as selective Na 1.7 channel blockers, with potential to be developed as leads for the treatment of chronic nocioceptive pain. ProTx-II is a 30-amino acid peptide with three disulfide bonds that has been reported to adopt a well-defined inhibitory cystine knot (ICK) scaffold structure. Potential drawbacks with such peptides include poor pharmacodynamics and potential scrambling of the disulfide bonds in vivo.
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