Francisco M. Barriga
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SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence - Nature Cancer
Abstract The role of driver gene mutations in sustaining tumor growth at metastatic sites is poorly understood. SMAD4 inactivation is a paradigm of such mutations and a hallmark of pancreatic ductal adenocarcinoma (PDAC). To determine whether metastatic tumors are dependent on SMAD4 inactivation, we developed a mouse model of PDAC that enables spatiotemporal control of Smad4 expression.
Publisher Correction: Metabolic adaptations direct cell fate during tissue regeneration - Nature
Correction to: Nature https://doi.org/10.1038/s41586-025-09097-6 Published online 11 June 2025 In the version of the article initially published, in the top panel of Fig. 1b, the labels “ISCs” and “Abs” were switched and have now been amended so that the labels read (from top to bottom) “ISCs, Abs, Sec” in the HTML and PDF versions of the article.
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