Francisco Navarrete Rueda

1. Introduction The relationship of health with long-chain omega-3 fatty acids – also referred to as long chain polyunsaturated fatty acids or n-3 fatty acids (n-3 FA) - mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – was discovered in 1979 (1) and a plethora of studies have been carried since then, reflecting an increasing interest in the prognostic value of their body levels (2). The main dietary source of n-3 FA intake is fish (especially fatty species).

1 Introduction Cannabis is the most widely used illicit drug in the United States, with 18.7% of the population aged 12 or older reporting past year use (Key Substance Use and Mental Health Indicators in the United States: Results from the 2021 National Survey on Drug Use and Health, U.S. Department of Health and Human Services, 2021).

Introduction The use of cannabis and other cannabinergic drugs during adolescence, a developmental period when the brain undergoes maturation, is widespread and continues to grow (Bava et al., 2010; Peters et al., 2022).