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François-Xavier E. Beau on Muck Rack

François-Xavier E. Beau

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Articles

A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair

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By Shwathy Ramesan, Joel Mason, Sandeep Kumar, Denis Korneev, Samuel Mills, Yasith Mathangasinghe, Aarón Andrés, Tyra D. Fraser, Katherine Lewis, Stephanie Chua, Natasha Kapoor-Kaushik, Lewis Williams, Miran Mrkela, Bradley Turner, Georg Ramm, Heejung Shim, David Gonsalvez, Samantha Barton, Molly E. V. Swanson, Lijun Loh, François-Xavier E. Beau, Matthew V. Rutar
| Nature Verified
Abstract There are no currently approved therapies that promote new myelin formation after myelin damage, which can, in part, be attributed to a lack of reliable systems that can reproducibly model these processes. Here we engineered a human iPSC-derived spheroid model enriched with mature, myelinating oligodendrocytes and functionally reactive microglia.
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