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Articles by Frank Surup
Structurally diverse secondary metabolites from the dung-inhabiting fungus Botryotrichum murorum
Abstract A combination of confidence-aware MS/MS-based metabolomics and conventional chemical screening approaches was employed to investigate the metabolome of Botryotrichum murorum DSM 113281, isolated from tortoise dung. The metabolomic survey revealed a high degree of chemical diversity; however, low production rates necessitated large-scale solid-state cultivation to purify the major constituents.
Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators
ATG autophagy-related CASM conjugation of ATG8 to single membranes CCCP carbonyl cyanide m-chlorophenylhydrazone GFP green fluorescent protein IAV Influenza A virus LAMP2 lysosome-associated membrane protein 2 LC3 microtubule-associated protein 1A/1B-light chain 3 LDELS LC3-dependent extracellular vesicle loading and secretion LR Lagotto Romagnolo MAPK mitogen-activated protein kinases MDCK Madin-Darby canine kidney MOI multiplicity of infection mTOR mammalian target of rapamycin NOP14...
Cytochalasins from the Ash Endophytic Fungus Nemania diffusa DSM 116299
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Heimionones A–E, New Sesquiterpenoids Produced by Heimiomyces sp., a Basidiomycete Collected in Africa
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Secondary Metabolites from Fungi—In Honor of Prof. Dr. Ji-Kai Liu’s 60th Birthday
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessEditorial by Tao Feng 1,* and Frank Surup 2,* 1 School of Pharmaceutical Sciences, South-Central Minzu University, 430074 Wuhan, China 2 Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH, 38124 Braunschweig, Germany * Authors to whom correspondence should be addressed. J.
Biosynthesis of oxygenated brasilane terpene glycosides involves a promiscuous N-acetylglucosamine transferase
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Angewandte Chemie International Edition
AbstractCrocagin?A (1) combines an attractive molecular structure with an unusual biosynthesis and bioactivity. An efficient synthesis of crocagin?A is presented that hinges on an early formation of the heterotricyclic core, an electrophilic amination, and the stereoselective hydrogenation of a tetrasubstituted double bond. This synthesis confirms the absolute configuration of crocagin?A and provides access to the natural product and derivatives thereof for further biological testing.
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