Dirk Trauner on Muck Rack

Dirk Trauner

Philadelphia, Seattle
As seen in: Arthritis & Rheumatology, Color Research & Application, Nature, Wiley Online Library, PNAS, ACS Publications, Analytical Chemistry, Royal Society of Chemistry, Cell Chemical Biology, Cell Press
Penn Integrates Knowledge Professor, Natural Product Aficionado, Photopharmacologist, Fox Terrierist, and Unfulfilled Architect. #firstgen
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Articles

Photocontrolled trimethoprim PROTACs targeting the eDHFR protein tag - Nature Communications

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By Tommy Nguyen, Tommy Nguyễn, Angela Gong, Dirk Trauner
| Nature Verified
Abstract Proteolysis targeting chimeric small molecules (PROTACs) offer a strategy for degrading disease-associated proteins or controlling engineered protein tags fused to therapeutic proteins, like chimeric antigen receptors (CARs). New approaches are needed that allow spatiotemporal control of PROTAC activity, restricting degrader activity to targeted cells. Photopharmacology offers a solution by enabling light-mediated spatial control of drug action.
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Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation - Nature Communications

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By Florian Küllmer, Veselin Nasufovic, Michaela Frolikova, Dirk Trauner, Hans-Dieter Arndt, Katerina Komrskova, Magdalena Zernicka-Goetz, David Glover
| Nature Verified
Abstract Mammalian oocytes are notoriously prone to chromosome segregation errors leading to aneuploidy. The spindle provides the machinery for accurate chromosome segregation during cell division. Mammalian oocytes lack centrioles and, therefore, mouse meiotic spindle relies on the organization of numerous acentriolar microtubule organizing centers into two poles (polar microtubule organizing centers, pMTOCs).
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Breaking a Lewis Acidity Trend for Rare Earths by Excited State Quenching

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By Randall K. Wilharm, Michael Gau, Dirk Trauner, Eric J Schelter
| dx.doi.org
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