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Franklin Chien

As seen in: BioRxiv
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Articles

Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity with High-Density Progenitor Cell Regions Correlating with High-Risk Disease

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By Marina E. Michaud, Mojtaba Bakhtiari, Franklin Chien, Chanel Schroff
| BioRxiv
Abstract The tumor microenvironment (TME) of medulloblastoma (MB) significantly influences tumor progression and therapy response, presenting a promising target for therapeutic advances. Prior single-cell analyses have characterized the cellular components of the TME but lack spatial context. To address this, we performed spatial transcriptomic sequencing on sixteen pediatric MB samples obtained at diagnosis, including two matched diagnosis-relapse pairs.
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