Fransis K. Buadi on Muck Rack

Fransis K. Buadi

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The clinical impact of acquired von Willebrand syndrome secondary to Waldenström macroglobulinemia: an underrecognized source of major bleeding events | Leukemia

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By Saurabh Zanwar, Jonas Paludo, Ronald S. Go, Joselle M. Cook, Sikander Ailawadhi, Thomas M Habermann, Thomas E Witzig, Morie A Gertz, David Dingli, Angela Dispenzieri, Nelson W. Y. Leung, Shaji Kumar Verified, Vincent Rajkumar, Stephen Ansell, Prashant Kapoor, Fransis K. Buadi
| Nature Verified
An under-recognized source of bleeding in Waldenström macroglobulinemia (WM) is the development of an acquired von Willebrand syndrome (AVWS) [1]. In WM, the von Willebrand Factor (vWF) glycoprotein can be degraded due to autoantibody destruction, increased shear stress due to hyperviscosity, or sequestered due to adsorption onto malignant cells, leading to the development of AVWS (AVWS-WM) [1, 2].
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