Franz Felix Konen

Abstract The dual-hit model of schizophrenic psychoses suggests that epigenetic alterations may contribute to the disease pathogenesis. Given the significant synaptic loss in patients with schizophrenia (SZ) during puberty, we investigated DNA-methylation patterns of key synaptic target molecules: dopamine transporter (DAT), dopamine receptor D2 (DRD2), microtubule-associated protein tau (MAPT), and postsynaptic density protein 95 (PSD95).

1 Introduction Magnetic resonance imaging (MRI) of the brain and the spinal cord is the most sensitive paraclinical method with respect to the detection of focal inflammatory demyelinating lesions and has been incorporated into the first version of the McDonald diagnostic criteria and the subsequent revisions facilitating the demonstration of lesion dissemination in space (DIS) and in time (DIT) [1-5].

Methods Literature research (NIH National Library of Medline PubMed.gov database, https://pubmed.ncbi.nlm.nih.gov/) was conducted until December 2024 to describe the effects of different approved or investigated MS-DMT on MS and RA and vice versa. Search terms were the respective DMT for MS or RA and “multiple sclerosis” or “rheumatoid arthritis” (for example “ocrelizumab AND rheumatoid arthritis”, “tocilizumab AND multiple sclerosis”). More than 500 publications were screened for eligibility.