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Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines - Leukemia
Abstract Targeted therapeutics for high-risk cancers remain an unmet medical need. Here we report the results of a large-scale screen of over 11,000 molecules for their ability to inhibit the survival and growth in vitro of human leukemic cells from multiple sources including patient samples, de novo generated human leukemia models, and established human leukemic cell lines.
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