Frédéric Barbut

Abstract Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in preterm infants. Early diagnosis remains challenging because clinical signs are nonspecific. We evaluated whether stool biomarkers could discriminate preterm infants with NEC from those without NEC. We performed an ancillary analysis within the multicenter ClosNEC cohort of infants born before 32 weeks’ gestation.

Abstract Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger that coordinates lifestyle transitions, virulence, and developmental processes in bacteria. In Clostridioides difficile, elevated c-di-GMP levels inhibit sporulation, but the underlying mechanism remained unclear. Here, we identified a conserved family of small, membrane-associated proteins encoded by c-di-GMP riboswitch-regulated genes.

Abstract Background: Clostridioides difficile is an anaerobic, spore-forming entero-pathogen, causing diarrhea in humans and animals. We aimed to evaluate C. difficile occurrence, diversity, virulence and putative circulation among French Equidae. Methods: We took advantage of necropsies of Equidae in Normandie, France, from 2019 to 2021 (n=100), to systematically recover the caecal content and, if watery and possibly diarrheal, any intestinal content. We searched for C.