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Frederic G. Barr on Muck Rack

Frederic G. Barr

As seen in: Color Research & Application, MDPI
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Articles

The PAX Genes: Roles in Development, Cancer, and Other Diseases

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By Frederic G. Barr, Aykut Üren, Taryn Shaw
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma

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By Javed Aziz Khan, Steve Hewitt Verified, Puspa R. Pandey, Bishwanath Chatterjee, Mary E. Olanich, Markku M. Miettinen, Frederic G. Barr
| Color Research & Application Verified
The?PAX3-FOXO1?fusion gene is generated by a 2;13 chromosomal translocation and is a characteristic feature of an aggressive subset of rhabdomyosarcoma (RMS). To dissect the mechanism of oncogene action during RMS tumourigenesis and progression, doxycycline-inducible PAX3-FOXO1 and constitutive MYCN expression constructs were introduced into immortalised human myoblasts.
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