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Fredrik Kartberg

As seen in: The Journal of Biological Chemistry
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Articles by Fredrik Kartberg

Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part

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By Esben Trabjerg, H. Lundbeck A, Fredrik Kartberg, Søren Christensen
| The Journal of Biological Chemistry Verified
Nerve growth factor-? (NGF) is essential for the correct development of the nervous system. NGF exists in both a mature form and a pro-form (proNGF). The two forms have opposing effects on neurons: NGF induces proliferation, whereas proNGF induces apoptosis via binding to a receptor complex of the common neurotrophin receptor (p75NTR) and sortilin. The overexpression of both proNGF and sortilin has been associated with several neurodegenerative diseases.
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Conformational characterization of Nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part

|
By H. Lundbeck A, Søren Christensen, Esben Trabjerg, Fredrik Kartberg
| The Journal of Biological Chemistry Verified
Nerve growth factor-? (NGF) is essential for correct development of the nervous system. NGF exists both in a mature and a pro-form (proNGF). The two forms have opposing effects on neurons, in which NGF induces proliferation, while proNGF induces apoptosis via binding to a receptor complex of the common neurotrophine receptor (p75NTR) and Sortilin. Overexpression of both proNGF and Sortilin has been associated with several neurodegenerative diseases.
Open in Who Shared Issue with article?
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