Freeha Hafeez

Cloke–Wilson rearrangement: a unique gateway to access five-membered heterocycles Cyclopropanes are of great synthetic value in heterocyclic chemistry due to their highly reactive nature. They are widely employed to synthesize various biologically active organic compounds. Generally, vinyl, carbonyl, imine, and alkylidene cyclopropanes are utilized as efficient synthetic precursors in organic synthesis.

3. Results and Discussion 3.1. Synthetic Chemistry of 1-Tosyl piperazine-dithiocarbamate Hybrid Derivatives 4a–j The synthesis of titled 1-tosyl piperazine-dithiocarbamate hybrid derivatives 4a–j was achieved by employing the following methodology: The precursor 1-tosyl piperazine 2 was prepared by treating anhydrous piperazine 1 with p-toluenesulfonyl chloride in dichloromethane (DCM).