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Articles by Friederike Ebner
Dissociation method influences immune cell composition in porcine tonsil cell suspensions
Abstract Introduction: Porcine tonsils are follicle-rich secondary lymphoid organs positioned at the oropharyngeal interface. In pigs, a major livestock species, they serve as a primary barrier against inhaled and ingested pathogens and play a central role in mucosal immunity. Despite their importance as a point of entry and as a reservoir for numerous pathogens, the cellular landscape driving tonsillar immune responses in pigs remains insufficiently defined.
TP53 loss attenuates C1q-associated macrophage remodeling in early adenomatous polyps in a porcine FAP model
Abstract Background: Familial adenomatous polyposis (FAP) is a hereditary condition that almost invariably leads to colorectal cancer. While TP53 inactivation is well established as a late event in the adenoma-to-carcinoma sequence, its functional role during the early stage of colorectal polyp development remains unclear. Methods: Three lines of FAP pigs were generated: APC1311/+, APC1311/+/TP53+/-, and APC1311/+/TP53-/-.
Trilateral Relationship: Ascaris, Microbiota, and Host Cells
Highlights Recent studies are uncovering a complex interplay between gastrointestinal helminths, gut microbes, and the immune system. Parasitic helminth infections are associated with alterations to the intestinal microbiome and metabolome, and these interactions are thought to influence host susceptibility to infections with nematodes and bacterial pathogens.
The domestic pig as human‐relevant large animal model to study adaptive anti‐fungal immune responses against airborne Aspergillus fumigatus
Research Article|Basic Olaf Kniemeyer Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI, ), Jena, Germany and Department of Microbiology and Molecular Biology, Institute for Microbiology, Friedrich Schiller University Jena, Jena, Germany Search for more papers by this author Axel A.
CD4 + T h immunogenicity of the Ascaris spp . secreted products
Abstract Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines. The parasite-secreted products represent the most relevant, yet complex (>250 proteins) antigens of Ascaris spp. as defining the pathogen-host interplay. We applied an in vitro antigen processing system coupled to quantitative proteomics to identify potential CD4+ Th cell epitopes in Ascaris-secreted products.
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