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Fritzh Nagae

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Mechanistic models of asymmetric hand-over-hand translocation and nucleosome navigation by CMG helicase

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By Yutaka Murata, Masataka Yamauchi, Shoji Takada, Fritzh Nagae
| biorxiv.org
Abstract Faithful replication of eukaryotic chromatin requires the CMG helicase to translocate directionally along single-stranded DNA (ssDNA) while unwinding double-stranded DNA (dsDNA) and navigating nucleosomes. However, the mechanism by which CMG achieves processive translocation and deals with nucleosomal barriers remains incompletely understood.
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