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Fu Hui

As seen in: Nature, Frontiers in Immunology
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Articles by Fu Hui

A Joint Numerical Simulation Method for Mine Seismic-Electric Coupling

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By Zhang Guochuan, Fu Hui, Zhou Guoyou
| Preprints.org
You are already at the latest version With the continuous increase in coal mining depth in China, concealed geological structures—such as collapse columns and faults—pose a severe threat to mine safety by inducing water inrush accidents. Mine DC resistivity methods exhibit high sensitivity to the water-bearing characteristics of geological bodies but suffer from limited resolution. In contrast, mine seismic exploration offers high resolution but shows weak responses to water-rich bodies.
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Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription

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By Yan Liu, Ningning Wang, Zhenhua Li, Fu Hui, Xinlei Wang, Gaoyan Tang, Qingyun Zhang, Guohua Yu, Shuzhen Liu, Yanhong Ding
| Nature Verified
Abstract Immune evasion driven by aberrant PD-L1 expression poses a significant challenge to the efficacy of cancer immunotherapy. Although Mitofusin-2 (MFN2) is recognized for its role in tumor suppression, its specific contribution to the regulation of immune escape remains poorly understood. Here, we integrated analyses of public datasets, clinical specimens, and mechanistic experiments in multiple cancer cell lines, immunocompetent mouse models, and patient-derived organoids.
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Efficacy and prognostic analysis of chemo-immunotherapy after TKI resistance in EGFR-mutant non-small cell lung cancer with TP53 or KRAS co-mutations

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By Yuhui Nie, Chen Song, Kun Wu, Mingxin Yu, Jia Hu, Shuzhen Liu, Fu Hui
| Frontiers in Immunology
1 Introduction Lung cancer is one of the most prevalent and lethal malignancies worldwide, and it remains the leading cause of cancer-related death (1). The pathological types of lung cancer are mainly divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with NSCLC accounting for approximately 80%, including adenocarcinoma and squamous cell carcinoma (2, 3).
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