Fu-Ying Zhao

Abstract Metastasis remains the primary cause of breast cancer death, driven by organotropism to brain, lung, bone, and lymph nodes. Single-cell and spatial multi-omics reveal organotropism as an active ecological process orchestrated by crosstalk between tumor cells and stromal/immune compartments.

1 Introduction Alcohol use disorder (AUD) represents a profound global health burden, characterized by compulsive alcohol use and a high propensity for relapse, contributing to millions of deaths annually and incurring substantial socioeconomic costs [1]. Beyond its well-characterized effects on peripheral organs, chronic alcohol consumption inflicts profound damage on the central nervous system, leading to persistent cognitive deficits that severely impair quality of life and hinder recovery.