Fuat Emre Canpolat

Fetoscopic interventions have transformed the landscape of fetal medicine, offering hope for life-saving in utero treatments, particularly in conditions like twin-to-twin transfusion syndrome (TTTS).1 However, the clinical success of these techniques is constrained by a persistent complication: iatrogenic preterm premature rupture of membranes (iPPROM).

Some agents administered antenatally may have positive or negative effects on the fetus. Research has been published on many factors known to have very different effects on fetal lung development. This issue is still on the research agenda because it is safer and vitamins have been shown to be effective in experiments.

1. Introduction One of the most important steps in reducing neonatal morbidity is to prioritize noninvasive respiratory support and avoid invasive mechanical ventilation. However, the latter is used as rescue therapy in infants with severe respiratory distress. According to US Neonatal Research Network data for 2018, 84.3% of infants at <29 weeks of gestation received conventional mechanical ventilation support during their stay in the NICU [1].