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Fuh Yong Wong

As seen in: Nature, MDPI
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Articles

A multi-ancestry genome-wide study of tamoxifen metabolism and breast cancer recurrence

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By Chiea Chuen Khor, Whee Sze Ong, Elaine Hsuen Lim, Etienne Chatelut, Sylvia Chen, Jean Abraham, Natalia Sutiman, Sze Lee, Zheng Li, Kar Seng Sim, Diana M Eccles, William J. Tapper, Tom C Maishman, Stefan Winter Verified, Leila Dorling, Qi Guo, Carlos Caldas, Helena Earl, Louise Hiller, Janet Dunn, Yoon Sim Yap, Mabel Siu‐Chun Wong, Fuh Yong Wong, Rebecca Dent, Arafat Tfayli, Elke Schaeffeler, Ute Hamann, Matthias W. Beckmann, Florence Dalenc, Melanie White-Koning, Hiltrud Brauch, Werner Schroth, Wilfried Renner, Matthias Schwab, Fabienne Thomas, Balram Chowbay, Thomas E. Muerdter, Cecile Arellano, Nathalie K. Zgheib, Boian Ganchev, Peter Krippl, Uwe Langsenlehner, Tanja Langsenlehner, Michel Eichelbaum
| Nature Verified
Abstract Tamoxifen’s pharmacokinetics are strongly influenced by the highly polymorphic CYP2D6, while the influence of other genetic variants has been inconclusive. To further delineate this genotypic-phenotypic impact, we conducted a multi-ancestry genome-wide association study in 636 hormone-receptor-positive (HR+) breast cancer (BC) patients treated with 20 mg tamoxifen daily for ≥8 weeks and validated these genetic determinants in another 869 patients.
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Determining the Need for Metastatic Staging in Patients with Bilateral Breast Cancers

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By Verónica Alcántara, Fuh Yong Wong, John Allen, Veronica Siton
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Open in Who Shared Issue with article?

Is Metastatic Staging Needed for all Patients with Synchronous Bilateral Breast Cancers?

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By Fuh Yong Wong, John Allen, Jing Xue Hoo, Geok Hoon
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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