Fukino Kono on Muck Rack

Fukino Kono

As seen in: Cell Reports Physical Science
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Articles

Continuous bile excretion from polarized hepatocytes on a microchannel-patterned device

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By Fumiya Tokito, Hiroshi Arakawa, Yuya Nakazono, Mathieu Danoy, Hyunjin Choi, Jingjing Yang, Satoshi Yamasaki, Natsuko F Inagaki, Taichi Ito, Kenpei Tai, Hiroyuki Kusuhara, Yusuke Masuo, Yukio Kato, Ikumi Tamai, Takeshi Katsuda, Masaki Nishikawa, Yasuyuki Sakai, Mikito Kiyofuji, Fukino Kono, Katsuhiro Esashika
| Cell Reports Physical Science Verified
Keywords liver hepatocyte bile excretion microphysiological system liver-on-a-chip microfabrication hepatocyte polarization CLDN1 drug discovery cholestasis Introduction Bile excretion is a vital hepatic function that helps maintain body homeostasis.1 When synthesized by hepatocytes, bile facilitates lipid digestion, cholesterol regulation, and the elimination of drugs as well as metabolic byproducts.2,3,4 Following secretion into the intestine, some bile components, including bile acids and...
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