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A bioartificial and vasculomorphic bone matrix‐based organoid mimicking microanatomy of flat and short bones
1 INTRODUCTION A number of studies have shown that decellularized bone matrices exert a powerful in vivo and in vitro inductive action on bone cell adhesion, proliferation, and mineral deposition by either osteoblasts or skeletal osteoprogenitors including mesenchymal stromal cells (MSCs), human embryonic stem cells, induced pluripotent stem cells, and adipose-derived stem cells.1, 2 However, these models may in vitro display functional limitations including insufficient transport of...
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