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Adaptive Seamless Phase II/III Randomization Test Considering Treatment Group Selection Based on Short-Term Binary Outcomes

Feb 04, 2026 |

By Kohei Uemura, Junki Mizusawa, Yutaka Matsuyama, Funato Sato

| Wiley Online Library

1 Introduction In recent years, innovative clinical trial design methodologies that enable efficient drug development have garnered increasing attention [1]. Conventional clinical trials are conducted strictly according to a protocol defined before trial initiation.

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Adaptive Seamless Phase II/III Randomization Test Considering Treatment Group Selection Based on Short-Term Binary Outcomes

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