Furr Stimming

Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization of potentially disease-causing, protein-altering and splicing mutations in 710 cases and 11,827 controls from genetically predicted African or African admixed ancestries.

BLAAC PD Study Core Team Andrew Singleton, PhD Center for Alzheimer’s Disease and Related Dementias, Laboratory of Neurogenetics, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD Cornelis Blauwendraat, PhD Coalition for Aligning Science, Chevy Chase, MD, USA Lana Chahine, MD University of Pittsburgh, Pittsburgh, PA Sara Bandres Ciga, PharmD, MS, PhD Center for Alzheimer’s Disease and Related Dementias,...

Introduction The renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics, well known for its pivotal role in the regulation of water and sodium homeostasis and blood pressure (Paul et al., 2006b). It involves the enzymatic conversion of angiotensinogen to angiotensin (Ang) I by renin. Through the classical pathway, Ang I may be converted to Ang II via the angiotensin-converting enzyme (ACE).