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Fuyin Deng

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Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca 2+ -mediated increases in astrocytic cholesterol

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By Zhan Zhang, Shaojian Li, Liang Xu, Songhua Xiao, Yi Li, Jialin Huang, Jingxuan Huang, You Zuo, Wenjie Wen, Qingyuan Dai, Chuan Xiao, Xinkai Zhang, Jiongxue Chen, Fuyin Deng, Jinbiao Li, Yongteng Xu, Xia Hu, Zhenhong Deng, Yuan Luo, Xiaoru Xie, Xiaojing Ye, Wei-Jye Lin, Yamei Tang
| Nature Verified
Abstract Disruptions in the glymphatic system and its downstream meningeal lymphatic drainage pathway, crucial for brain waste clearance, are linked to the pathogenesis of Alzheimer’s disease (AD), yet the underlying mechanisms remain unclear. Abnormal calcium dynamics in astrocytes represents an early event in the mouse models of AD.
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