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G. Barzon on Muck Rack

G. Barzon

As seen in: Color Research & Application
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Articles

Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours

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By S. Sabattini, G. Barzon, M. Giantin, R. M. Lopparelli, M. Dacasto, D. Prata, G. Bettini
| Color Research & Application Verified
This study investigated Kit receptor dysregulations (cytoplasmic immunohistochemical expression and/or c-KIT mutations) in cats affected with splenic mast cell tumours. Twenty-two cats were included. Median survival time was 780 days (range: 1–1219). An exclusive splenic involvement was significantly (P = 0.042) associated with longer survival (807 versus 120 days). Eighteen tumours (85.7%) showed Kit cytoplasmic expression (Kit pattern 2, 3). Mutation analysis was successful in 20 cases.
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