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Abstract Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient tissue that offer a powerful complement to cell lines1.
Highlights • PARP inhibitors have opened the era of targeted therapy in ovarian cancer; • Major therapeutic improvements have been limited to the high grade serous subtype; • The panorama of possible clinically actionable targets in ovarian cancer is wider. • New druggable alterations and matched drugs are under investigation.
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