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S. Barthorpe

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A tumour-derived organoid biobank maps cancer gene dependencies

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By R. Ansari, J. L. Davis, J. Doran, K. L. Evans, M. Fekry, C. M. Hall, C. Hardy, L. Holland, N. Joshi, K. May, J. R. Morris, S. Russ Price, K. W. Smith, F. Thomas, S. Walker, A. C. Freeman, G. Giannone, N. Grehan, E. A. Griffiths, S. L. Lee, E. Leung, A. Mirnezami, A. M. Redmond, K. D. Roberts, S. Roy, D. A. Sanders, P. Taniere, OCCAMS Consortium, J. D. Brenton, I. A. McNeish, A. Biankin, O. J. Sansom, T. J. Underwood, R. C. Fitzgerald, A. D. Beggs, M. J. Garnett, C. Herranz-Ors, S. G. Bhosle, A. E. Beck, J. G. R. Gilbert, G. Picco, J. Espejo Valle-Inclan, F. Muyas, S. Valentini, A. E. Andres, S. Barthorpe, G. Battarbee, C. M. Beaver, S. Brocklesby, J. Cantwell, C. A. Collins, H. G. Dimitrova, E. Efendi, T. A. Fowler, M. Garcia-Casado, J. A. T. Griffiths, R. Hamer, Z. Hewitson, E. Hitch, D. A. Jackson, A. Kavasakali, L. Letchford, H. B. Lightfoot, H. Lingala, I. Mali, T. Mironenko, C. Pacini, G. Robert-Tissot, H. A. Rogers, J. V. Smith, E. Souster, W. J. Spence, S. F. Vieira, G. Alfonsin, H. Bermingham, H. Coles, D. P. Ennis, C. Loreno, C. Millington, B. Nutzinger, K. Orzechowska, C. M. A. Pinna, M. Vias, K. Wanigasooriya, M. R. Stratton, L. M. Staudt, U. McDermott, I. Cortes-Ciriano, H. E. Francies
| Nature Verified
Abstract Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient tissue that offer a powerful complement to cell lines1.
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