Editor's Pick Host Response and Inflammation | Spotlight S. Bishu, G. Hou, M. El Zaatari, S. R. Bishu, D. Popke, M. Zhang, H. Grasberger, W. Zou, R. W. Stidham, P. D. R. Higgins, J. R. Spence, N. Kamada, J. Y. Kao Manuela Raffatellu, Editor DOI: 10.1128/IAI.00295-19 ABSTRACT Tissue-resident memory T cells (TRM cells) are a novel population of tissue-restricted antigen-specific T cells. TRM cells are induced by pathogens and promote host defense against secondary infections.