Gabriele Piacenti

Abstract In response to stress, cells exploit plasticity to self-activate and form protrusions that explore the environment and guide migration. While protrusion initiation is well characterized, their maturation and functional composition remain poorly understood. Here, using a new pooled genetic approach (ReGenT-seq) to interrogate chromatin factors controlling epidermal progenitor activation, we unexpectedly identified Cbx3 as a critical determinant of protrusion formation.

Abstract Skin homeostasis depends on interactions between epithelial cells and the microbiome mediated by molecular and biochemical factors. Perturbations of this interplay are linked to inflammatory disorders, including wound healing and cancer. While research has mainly illuminated shifts in microbial community composition, novel computational approaches are starting to reveal the host-microbe functional interactome in the cutaneous ecosystem.

As the outer organ of the body, the skin has many roles, from defending against microbes to regulating body temperature and sensations. To exercise these duties, it takes advantage of various types of cells, tissues and glands. Sebaceous glands – which are found in hair follicles all over the body, apart from the palms of our hands and the soles of our feet – produce a lipid-rich liquid called sebum, which prevents the skin from becoming too dry.