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Gabriella Smith

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Articles

An Interactive, Case-Based Microbiology Laboratory Session for First-Year Medical Students

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By Gabriella Smith, Julia Hankins, Eric Karney
| The Cureus Journal of Medical Science
Specialty Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Biostatistics Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional.
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Deletion of Endocannabinoid Synthesizing Enzyme DAGLα in Pcp2-Positive Cerebellar Purkinje Cells Decreases Depolarization-Induced Short-Term Synaptic Plasticity, Reduces Social Preference, and Heightens Anxiety | eNeuro

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By Gabriella Smith, Emma Grant
cannabinoid cerebellum DAGLα DSE DSI Purkinje Significance Statement Deletion of the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha from mouse cerebellar Purkinje cells (PCs) alters motor and social behaviors, disrupts short-term synaptic plasticity, and reduces PC activity during social exploration.
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Deletion of endocannabinoid synthesizing enzyme DAGLα in Pcp2-positive cerebellar Purkinje cells decreases depolarization-induced short-term synaptic plasticity, reduces social preference, and heightens anxiety

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By Gabriella Smith, Kathleen McCoy, Emma Grant
Abstract The endocannabinoid (eCB) signaling system is robustly expressed in the cerebellum from embryonic developmental stages to adulthood. It plays a key role in regulating cerebellar synaptic plasticity and excitability, suggesting that impaired eCB signaling could lead to deficits in cerebellar adjustments of ongoing behaviors and cerebellar learning. Indeed, human mutations in DAGLα are associated with neurodevelopmental disorders.
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