Gadiel Saper

Abstract Cells and organs constantly experience mechanical forces. Neurons, in particular, are exposed to such stimuli during development, aging, disease, and normal activities like movement and homeostasis. Recent studies highlight the key role of microtubules (MTs) in mechanotransduction, adjusting cytoskeletal dynamics in response to mechanical cues. While the effects of acute forces on MTs are known, the impact of repetitive mechanical stimuli over time remains unclear.

Communication Anna C. Impastato, Anna C. Impastato orcid.org/0000-0001-8919-8313 Department of Chemistry, New York University, New York, 10003 USA These authors contributed equally to this work. Search for more papers by this author Andrej Shemet, Andrej Shemet Department of Chemistry, New York University, New York, 10003 USA These authors contributed equally to this work. Search for more papers by this author Nynke A. Vepřek, Nynke A.

Gadiel Saper https://orcid.org/0000-0002-3556-7977, Stanislav Tsitkov, Parag Katira, and Henry Hess https://orcid.org/0000-0002-5617-606X Abstract Supplementary Materials REFERENCES AND NOTES Abstract The active assembly of molecules by nanorobots has advanced greatly since “molecular manufacturing”—that is, the use of nanoscale tools to build molecular structures—was proposed.