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Gage M Pyles on Muck Rack

Gage M Pyles

As seen in: PLOS ONE, BioRxiv
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Articles

Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge

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By Kelly Weaver, M. Wolf, Gage M Pyles, Graham J. Bitzer
| PLOS ONE
Citation: Weaver KL, Bitzer GJ, Wolf MA, Pyles GM, DeJong MA, Dublin SR, et al. (2023) Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge. PLoS ONE 18(11): e0286925. https://doi.org/10.1371/journal.pone.0286925 Editor: Paulo Lee Ho, Instituto Butantan, BRAZIL Received: December 6, 2022; Accepted: May 25, 2023; Published: November 2, 2023 Copyright: © 2023 Weaver et al.
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Addition of adjuvant to DTaP modulates vaccine-induced immunological responses but is insufficient to improve protection in CD-1 mice

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By Kelly Weaver, Sarah Miller, Gage M Pyles, Spencer R Dublin
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.03.03.530983 Abstract Pertussis is a vaccine-preventable respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. While vaccination rates remain high in developed countries, incidence of pertussis has increased following the transition from wP vaccines to aP vaccines. The reemergence of pertussis is attributed, in part, to waning immunity induced by aP vaccination.
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