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Gai-Ping Zhang on Muck Rack

Gai-Ping Zhang

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Articles

Infectious bursal disease virus VP3 triggers NLRP3 inflammasome activation via VDAC-mediated mitochondrial DNA release

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By Haojie Ren, Qing-Qing Xu, Shichong Han, Xiangtao Kang, Yuhang Zhang, Wencheng Lin, Yu-He Ma, Jun-Hao Fan, Meng-Ting Zhou, Xiao-Ya Pan, Meng-Hui Zi, Han-Cheng Shao, Gai-Ping Zhang
| Nature Verified
Abstract Mitochondria play central roles in regulating innate immune responses, particularly in inflammatory processes. In response to viral infection, mitochondria can initiate processes such as mitophagy, mitochondrial DNA (mtDNA) release, and apoptosis, thereby determining the fate of stressed cells. Infectious bursal disease virus (IBDV) is a highly contagious pathogen that causes typical inflammatory symptoms in chickens.
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