Gaia Alessandra Kullmann

Abstract Tuberous Sclerosis Complex (TSC) is a multisystem human genetic disorder frequently associated with early-onset epilepsy. Neonatal seizures are increasingly recognized. Detailed neonatal electroclinical characterization remains limited. We conducted a multicentre retrospective study across 16 Italian centres, including 32 neonates (term and preterm) with definitive diagnosis of TSC and at least one EEG- or video-EEG–confirmed seizure during neonatal period.