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Galván del Rey

As seen in: Biomed Central (BMC)
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Articles

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease - Molecular Neurodegeneration

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By LabEx DISTALZ, Université de Lille, Galván del Rey
| Biomed Central (BMC)
The overall aim of our study was to assess the phenotypic and functional effects of a Finnish founder mutation, 5.2 kb TYROBP deletion, that is known to cause the early-onset neurodegenerative disease NHD in biallelic state. We hypothesized that the monoallelic TYROBP deletion may be a risk factor for neurodegeneration later in life and may induce functional changes in the microglial cells.
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